Peptide Database

Peptide NameSLAY-screened peptide P519

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC96H138N26O37S

DescriptionStandard

        TGLSNDHGDYYSQSKCGEVGY
    

Molecular Weight2280.34 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-2.52

Net Charge (pH 7.4) -2.79

Charge Density (pH 7.0) -0.1202

GRAVY Index-1.08

Hydrophobic Moment 0.28

Boman Index-0.07

Instability Index24.84

Aliphatic Index 32.38

Aromaticity 0.1429

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1039.71

LogP -14.50

H-bond Donors 37.0

H-bond Acceptors 37.0

Rotatable Bonds 73.0

Heavy Atoms 160.0

Ring Count 4.0

Amide Bonds 22.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0131354 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/