Peptide Database

Peptide NameRNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3`-phosphate 5`-hydroxy nucleic acid ligase)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Ligase

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length936 amino acids

Chemical FormulaC4619H7253N1229O1354S45

DescriptionStandard

        MYAKTIPVIWGCFFLWNLYSSSSQTIYPGIKARVTQRALDYGVQAGMEMIGQMLKERNIPDLQGSESLDFLKVDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANVSTNWAVKSPLFKDAGGANLFLSGVYFTGNIILNRNDFGQPLLKLEDCYAQVSHAHVSFFGQFSVLYNSFAEPMEKPILKNLNEMLCPIITGEVEALNVNLSTLEVLTKIDNYTLLDYSIIDSPEITENSLDVNFKGTFYPLENLVDPPFSPAPFVLPERSDSMLYIGISEYFFKSASFAYYTAGAFDVTFSTKEISNHLIQNSQGLGNVLSRIADIYILAQPFMVRIMATEPPIINLQPGNFSLDIPASIMMLTQPENSTMKTIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPEPKRSKIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPYNISFVNSDIEVLQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSPRAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASVEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEESEVECFEGSLLSRPLRRVILPCRLLSPTRM
    

Molecular Weight103108.34 Da

Isoelectric Point (pI)5.74

Net Charge (pH 7.0)-14.76

Net Charge (pH 7.4) -16.40

Charge Density (pH 7.0) -0.0158

GRAVY Index-0.00

Hydrophobic Moment 0.81

Boman Index0.11

Instability Index40.35

Aliphatic Index 93.54

Aromaticity 0.0876

Extinction Coeff. Reduced 76210.00

Extinction Coeff. Oxidized 76960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0245801 VERIFIED: YES

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyBPI/LBP

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Ligase Cytotoxic Non-hemolytic

TargetGram Negative Bacteria