Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length541 amino acids

Chemical FormulaC2655H4210N770O730S22

DescriptionStandard

        MGDVPVQPAHPPQDGHWRHRSLLPAATHMGSGPTMGPAAAVGHAPGSCRCPGADGSLPARVHLLSGATRGMWLCLLLLMAACVPTTTSSPGIKGRVTRSALEYGQRFGLELLRSLLQKEHNVNLQGSYQAPLLGRLNYTVPQIHIHELQMNDSTVDFAEDVGVQLTVHRARIQLNATWQAQLGAWQDSGSLRLRIRDLAVAVLLGLGADEHGHPSVWDAGCDARGTDLRLEFRRGQSWLYNLLVPLLQRTLRQQLNKQLCVEIQKGISRLQDSLKNMRVSAQLDPFAAIDLSLLGQPAIRKQHGDVGLKGEFFGVHGRWQNPFSAQPVGLPELQEPMLLVAITEFVANTAAFVYFTAGALRRNITAEMLPRRFPLKLNTESMGSFAPQLQQHFPSCPMELHLWARRQPLLSCHPNALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTAKPTIAGNRLGGTVGLQSLSVVQVMSHVGPLQVQKLENMLKFGLWLFGVPWANKRLRPGVPLPTPHGITLLHPHLSLHEGFMLITTDLRYEP
    

Molecular Weight59301.98 Da

Isoelectric Point (pI)9.45

Net Charge (pH 7.0)12.48

Net Charge (pH 7.4) 10.91

Charge Density (pH 7.0) 0.0231

GRAVY Index-0.05

Hydrophobic Moment 0.72

Boman Index0.09

Instability Index52.35

Aliphatic Index 97.38

Aromaticity 0.0647

Extinction Coeff. Reduced 63940.00

Extinction Coeff. Oxidized 64440.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0144051 VERIFIED: NO

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyBPI/LBP

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence