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MYP_120088
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Basic Information
Guentherin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
26 amino acids
C140H251N45O34S
Standard
Sequence
VIDDLKKVAKKVRRELLCKKHHKKLN
Physicochemical Analysis
3140.84 Da
10.23
6.90
6.55
0.2652
-0.92
0.86
-0.44
27.69
112.31
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1335.13
-9.15
48.0
44.0
118.0
220.0
2.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028093 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0038839 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Guentherin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
11.3 μM
MIC
PaperJ. Zhou et al. / Peptides 27 (2006) 3077-3084. Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri Evidence URLhttps://www.uniprot.org/uniprotkb/P84859/entry
RECORD: Rec_0062102 VERIFIED: YES
Provenance & Taxonomy
Rana guentheri [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus FDA209P
35.5 μg/mL
MIC
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/
RECORD: Rec_0133346 VERIFIED: YES
Provenance & Taxonomy
Rana guentheri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
64 μg/mL
MIC
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/
RECORD: Rec_0220330 VERIFIED: NO
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Antifungal Anti-Candida Non-hemolytic Non-ribosomal
Qualitative functional evidence
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/; https://www.uniprot.org/uniprotkb/P84859/entry; https://bblserver.org.in/ampdb/
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