Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2324H3670N584O675S25

DescriptionStandard

        MLQLVIVALMLLPYTCGQNPAIQVLLTNKGLQYGKHVGAGWIQDMLEHVTLPDIQGNFNTLIGTIQYTLSGLKITKCDFPEPNVEFSETFSGFKTTITGLNAALTGGWAIKYHIIHDGGSFDMAILGVDVTSVVSLGRNADGHLSVNSVSCDGEVQDVNIQLYGGSSWIINPFMNYIKGHIIDEIKSNICPAVQKSVEELESRLQAMNVSYAVNQVLSLELPLTRLPVFSPSNLNLGLKGEFYSIQTHAEPPFQSKPFTMPDLPGYMLSAGVSEFSLNSAAYGYFSAKKLQILITDSMIPKLFPFHLNTSSMGPYVPQLPKLLPGLLMNLNVYATEAPMFSVQSGFVNLTVQAAVKAAAIESNGSNVPLFTLKAVVMLGGKMWIADGRMKGSVMLNNFTLTLASTEVGPFKTDNLEKMCKNGIELFGLPQVNKKLAEGMMLPRMKHVTPVNSVLTVEEGFITISSDAQVLDVL
    

Molecular Weight51393.13 Da

Isoelectric Point (pI)5.74

Net Charge (pH 7.0)-6.73

Net Charge (pH 7.4) -7.57

Charge Density (pH 7.0) -0.0142

GRAVY Index0.20

Hydrophobic Moment 0.58

Boman Index0.21

Instability Index39.08

Aliphatic Index 100.74

Aromaticity 0.0825

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419013 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias melastigma [Bacterium]

FamilyBPI

Tax ID30732

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence