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MYP_119994
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Basic Information
TP1[F4G] (Derived from TP1)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
17 amino acids
C92H148N34O20S4
Standard
Sequence
KWCGRVCYRGICYRRCR
Physicochemical Analysis
2178.64 Da
9.93
5.72
5.45
0.3363
-0.71
0.63
-0.48
13.22
40.00
0.1765
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.69
-8.09
41.0
30.0
70.0
150.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242408 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained β-hairpin peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
3-16; 7-12
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antibacterial Antimicrobial
Bacillus subtilis ATCC 6051
0.5 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0250376 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained β-hairpin peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial
Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR; PmxR)
16 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0269831 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained β-hairpin peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
3-16; 7-12
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antibacterial Antimicrobial
Acinetobacter baumannii ATCC 700603
1 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0345992 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained β-hairpin peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
3-16; 7-12
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antibacterial Antimicrobial
Pseudomonas aeruginosa FADDI-FAO70
16 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0377603 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained β-hairpin peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial
Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR; PmxR)
2 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
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