Peptide Database

Peptide NameTP1[F4G] (Derived from TP1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC92H148N34O20S4

DescriptionStandard

        KWCGRVCYRGICYRRCR
    

Molecular Weight2178.64 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3363

GRAVY Index-0.71

Hydrophobic Moment 0.63

Boman Index-0.48

Instability Index13.22

Aliphatic Index 40.00

Aromaticity 0.1765

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 920.69

LogP -8.09

H-bond Donors 41.0

H-bond Acceptors 30.0

Rotatable Bonds 70.0

Heavy Atoms 150.0

Ring Count 4.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0176073 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial

TargetPseudomonas aeruginosa FADDIFA070 (PmxR)

Activity16 μg/mL

MethodMIC

RECORD: Rec_0183286 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Hemolytic Antimicrobial

Targethuman red blood cells

MethodHemolysis

RECORD: Rec_0203664 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

MethodQualitative experimental profile (exact peptide in linked primary study)

RECORD: Rec_0208148 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial

TargetKlebsiella pneumoniae BAA 2146 (NDM-1 pos)

Activity2 μg/mL

MethodMIC

RECORD: Rec_0220800 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial

TargetStaphylococcus aureus ATCC 43300 (MRSA)

Activity16 μg/mL

MethodMIC

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