Peptide Database

Peptide NameTP1[F4G] (Derived from TP1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC92H148N34O20S4

DescriptionStandard

        KWCGRVCYRGICYRRCR
    

Molecular Weight2178.64 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3363

GRAVY Index-0.71

Hydrophobic Moment 0.63

Boman Index-0.48

Instability Index13.22

Aliphatic Index 40.00

Aromaticity 0.1765

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 920.69

LogP -8.09

H-bond Donors 41.0

H-bond Acceptors 30.0

Rotatable Bonds 70.0

Heavy Atoms 150.0

Ring Count 4.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0020503 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial

TargetCryptococcus neoformans ATCC 208821

Activity2 μg/mL

MethodMIC

RECORD: Rec_0026668 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Cytotoxic Anticancer Antimicrobial

TargetMammalian cell cytotoxicity panel

MethodCytotoxicity assay

RECORD: Rec_0075478 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antimicrobial

TargetPseudomonas aeruginosa ATCC 27853

Activity1 μg/mL

MethodMIC

RECORD: Rec_0082443 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antifungal Antimicrobial

TargetAcinetobacter baumannii ATCC 19606

Activity0.5 μg/mL

MethodMIC

RECORD: Rec_0097775 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdisulfide-constrained β-hairpin peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antimicrobial

TargetAcinetobacter baumannii clinical isolate 100650661:1

Activity16 μg/mL

MethodMIC

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