Peptide Database

Peptide NameC-MP1-2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC78H136N20O16

DescriptionStandard

        IKWKKLLGAAKQIL
    

Molecular Weight1610.04 Da

Isoelectric Point (pI)10.48

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.2683

GRAVY Index0.26

Hydrophobic Moment 0.58

Boman Index0.12

Instability Index21.74

Aliphatic Index 153.57

Aromaticity 0.0714

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 604.58

LogP -0.89

H-bond Donors 21.0

H-bond Acceptors 20.0

Rotatable Bonds 58.0

Heavy Atoms 114.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007256 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 2) is lysine with the methyltrityl side chain. The Ⓖ (position: 8) is propargylglycine. Ⓚ (2) and Ⓖ (8) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetBacillus subtilis ATCC 23857

Activity128 μM

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/

RECORD: Rec_0084649 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 2) is lysine with the methyltrityl side chain. The Ⓖ (position: 8) is propargylglycine. Ⓚ (2) and Ⓖ (8) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus ATCC 25923

Activity256 μM

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/

RECORD: Rec_0226584 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 2) is lysine with the methyltrityl side chain. The Ⓖ (position: 8) is propargylglycine. Ⓚ (2) and Ⓖ (8) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetPseudomonas aeruginosa ATCC 27853

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/

RECORD: Rec_0307461 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 2) is lysine with the methyltrityl side chain. The Ⓖ (position: 8) is propargylglycine. Ⓚ (2) and Ⓖ (8) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli ATCC 25922

Activity128 μM

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/