Peptide Database

Peptide NamePolyphemusin I [R12-ins]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC114H176N42O22S4

DescriptionStandard

        RRWCFRVCYRGRFCYRKCR
    

Molecular Weight2615.15 Da

Isoelectric Point (pI)10.83

Net Charge (pH 7.0)7.72

Net Charge (pH 7.4) 7.45

Charge Density (pH 7.0) 0.4062

GRAVY Index-1.03

Hydrophobic Moment 0.60

Boman Index-0.67

Instability Index47.50

Aliphatic Index 15.26

Aromaticity 0.2632

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1102.69

LogP -8.79

H-bond Donors 49.0

H-bond Acceptors 34.0

Rotatable Bonds 84.0

Heavy Atoms 182.0

Ring Count 6.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0367380 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetCandida albicans

Activity2 μg/mL

MethodMIC

RECORD: Rec_0418437 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity100 % hemolysis at 42.6 μg/mL

MethodHemolysis

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