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MYP_119834
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Basic Information
Hyphancin-3D, ABP-dHC-Cecropin A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C185H316N56O46
Standard
Sequence
RWKIFKKIERVGQNVRDGIIKAGPAIQVLGTAKALGK
Physicochemical Analysis
4060.84 Da
11.17
6.76
6.54
0.1826
-0.19
0.91
-0.04
20.13
108.11
0.0541
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1683.84
-13.46
59.0
53.0
143.0
287.0
4.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211007 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Cancer cell lines: Leukemia cell lines K562
349.5 μM
IC50
PMID28347740 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28347740/
RECORD: Rec_0213834 VERIFIED: YES
Provenance & Taxonomy
Hyphantria cunea [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
<5 % hemolysis at 800 μM
Hemolysis
PMID25241628;28347740;28827052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241628/
RECORD: Rec_0229999 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0248480 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Hemolytic
human red cells
PMID28347740 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28347740/
RECORD: Rec_0261875 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Leukemia cell lines U937
303.2 μM
IC50
PMID28347740 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28347740/
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