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MYP_119834
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Basic Information
Hyphancin-3D, ABP-dHC-Cecropin A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C185H316N56O46
Standard
Sequence
RWKIFKKIERVGQNVRDGIIKAGPAIQVLGTAKALGK
Physicochemical Analysis
4060.84 Da
11.17
6.76
6.54
0.1826
-0.19
0.91
-0.04
20.13
108.11
0.0541
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1683.84
-13.46
59.0
53.0
143.0
287.0
4.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0128887 VERIFIED: YES
Provenance & Taxonomy
Hyphantria cunea [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0144406 VERIFIED: YES
Provenance & Taxonomy
Hyphantria cunea [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Alternaria sp. ATCC 20492
PMID25241628;28347740;28827052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241628/
RECORD: Rec_0158908 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Leukemia cell lines THP-1
228.5 μM
IC50
PMID28347740 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28347740/
RECORD: Rec_0176428 VERIFIED: YES
Provenance & Taxonomy
Hyphantria cunea [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Neurospora crassa ATCC 13837
32-64 μg/mL
MIC
PMID25241628;28347740;28827052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241628/
RECORD: Rec_0179071 VERIFIED: YES
Provenance & Taxonomy
Hyphantria cunea [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Rhizopus sp. ATCC 20577
64-128 μg/mL
MIC
PMID25241628;28347740;28827052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25241628/
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