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MYP_119816
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Basic Information
Defensin DefMT6
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
38 amino acids
C175H283N61O49S6
Standard
Sequence
GFGCPLNQGACHNHCRSIKRRGGYCSGIIKQTCTCYRK
Physicochemical Analysis
4217.89 Da
9.55
6.87
6.47
0.1808
-0.60
0.68
-0.18
74.60
43.68
0.0789
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1807.99
-24.05
71.0
64.0
140.0
291.0
6.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208165 VERIFIED: YES
Provenance & Taxonomy
Malpighian tubules [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
L. seeligeri
0.5 μM
MIC
PaperIxodes ricinus defensins attack distantly-related pathogens.
RECORD: Rec_0224662 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus,Ixodes scapularis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Listeria fleischmannii DSM 24998
1 μM
MIC
PMID26255244;27822206 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26255244/
RECORD: Rec_0227283 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus,Ixodes scapularis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Pseudomonas aeruginosa DSM 50071
2 μM
MIC
PMID26255244;27822206 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26255244/
RECORD: Rec_0264667 VERIFIED: YES
Provenance & Taxonomy
Ixodes scapularis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0275178 VERIFIED: YES
Provenance & Taxonomy
Malpighian tubules [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
Gram- Pseudomonas aeruginosa
2 μM
MIC
PaperIxodes ricinus defensins attack distantly-related pathogens.
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