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MYP_119789
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Basic Information
LP-54
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
25 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
YTSLIEELIKKSEEQQKKNEEELKX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0088795 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not fully specified; contains X placeholder [Modified]
Acetylation
Amidation
Contains X placeholder residue(s), The 'X' at position 25 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antiviral Antimicrobial
HIV-1 NL4-3; TZM-bl cells
0.000301±0.000026 μM
IC50
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0105809 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Contains X placeholder residue(s), The 'X' at position 25 is Lys-C16(palmitic acid)
Bio-Activity Profile
Anti-HIV-1 Fusion inhibition Antiviral
HIV-1 HXB2 | TZM-bl cells
0.000149±0.000048 μM
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | Chong H, Zhu Y, Yu D, He Y. | J Virol. 2018 Sep 26;92(20):e01088-18. | DOI:10.1128/JVI.01088-18 | PMID:30089693 PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0119664 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not fully specified; contains X placeholder [Modified]
Contains X placeholder residue(s), unspecified non-canonical residue at 25
Bio-Activity Profile
Antiviral
HIV-1 JRCSF
Virus inhibition assay
PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0203611 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not fully specified; contains X placeholder [Modified]
Acetylation
Amidation
Contains X placeholder residue(s), The 'X' at position 25 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antiviral Antimicrobial
HIV-1 JRCSF; TZM-bl cells
0.001796±0.00034 μM
IC50
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0224551 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not fully specified; contains X placeholder [Modified]
Contains X placeholder residue(s), unspecified non-canonical residue at 25
Bio-Activity Profile
Antiviral
HIV-1 HxB2
Virus inhibition assay
PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
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