Peptide Database

Peptide NameLL13-31

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC109H185N33O26

DescriptionStandard

        IGKEFKRIVQRIKDFLRNL
    

Molecular Weight2373.84 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.1979

GRAVY Index-0.46

Hydrophobic Moment 0.97

Boman Index-0.27

Instability Index17.98

Aliphatic Index 117.89

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1011.66

LogP -6.21

H-bond Donors 36.0

H-bond Acceptors 30.0

Rotatable Bonds 86.0

Heavy Atoms 168.0

Ring Count 2.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403337 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-Gram-positive Anti-Gram-negative Antibacterial Antimicrobial

TargetEscherichia coli (KCTC 1682)

Activity8 μM

MethodMIC

PaperProkaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37. Peptides. 2012 Jun;35(2):239-247. doi: 10.1016/j.peptides.2012.04.004. PMID: 22521196. PMID22521196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22521196/

RECORD: Rec_0418106 VERIFIED: YES