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MYP_119726
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological regulation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C13H16N2O6
Standard
Sequence
DY
Physicochemical Analysis
296.28 Da
4.05
-1.24
-1.44
-0.6199
-2.40
0.49
-0.32
5.00
0.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
149.95
-0.69
5.0
5.0
7.0
21.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0185460 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Enzyme inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
100.0 μM
IC50
PaperWu J., Aluko R. E., Nakai S.. Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006.
RECORD: Rec_0189009 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-Gram-negative Antibacterial Antimicrobial
Recombinant genetically engineered Escherichia coli surface-display system
-1.460 lfcMLE
SLAY screening (log2 fold-change MLE)
PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/
RECORD: Rec_0189355 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Enzyme inhibitory Antihypertensive
ACE
20000 μM
IC50
PaperStructural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides. PMID16448176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16448176/
RECORD: Rec_0278118 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
PaperStructure-taste correlation of L-aspartyl dipeptides using SIMCA method. J. Med. Chem., 29, 906-912, 1986
RECORD: Rec_0292891 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Regulatory
PaperZiganshin R. H., Svieryaev V. I., Vaskovsky B. V., Mikhaleva I. I., Ivanov V. T., Kokoz Y. M., Alekseev A. E., Korystova A. F., Sukhova G. S., Emelyanova T. G., Usenko A. B.. Bioactive peptides isolated from the brain of hibernating ground squirrel. Bioorg. Khim., 20, 899-918, 1994.
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