Peptide Database

Peptide NameNovel erythropoiesis stimulating protein (NESP)

Function Ontology

Anticancer

Antiviral

Hormonal / Endocrine ▸ Hormone peptide

Standard StatusStandard

Sequence Length166 amino acids

Chemical FormulaC815H1317N233O241S5

DescriptionStandard

        APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
    

Molecular Weight18395.92 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)2.96

Net Charge (pH 7.4) 2.57

Charge Density (pH 7.0) 0.0178

GRAVY Index-0.19

Hydrophobic Moment 0.86

Boman Index-0.02

Instability Index36.76

Aliphatic Index 96.45

Aromaticity 0.0663

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 22710.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7649.41

LogP -77.10

H-bond Donors 271.0

H-bond Acceptors 251.0

Rotatable Bonds 609.0

Heavy Atoms 1294.0

Ring Count 24.0

Amide Bonds 178.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0337298 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsThree N-linked carbohydrate chains

Bio-Activity Profile

Function

Stimulates erythropoiesis

MethodELISA

Half-LifeSubcutaneously injected into patients with end-stage renal failure, in vivo; 30600 s

RECORD: Rec_0349484 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Cricetulus griseus [Animal]

FamilyErythropoietin analog

Tax ID9606;10029

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hematopoietic Erythropoiesis-stimulating

PaperPubMed-linked source references: PMID:23847411; PMID:23338536; PMID:23325012; PMID:23243269; PMID:22803621; PMID:22192713; PMID:20140276; PMID:18837016; PMID:16179960 PMID23847411;23338536;23325012;23243269;22803621;22192713;20140276;18837016;16179960 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23847411/ PatentCA2165694

RECORD: Rec_0357700 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGrowth factor

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation

Bio-Activity Profile

Function

Antiviral Anticancer

Half-Life**Healthy volunteers:** The half life is approximately 4 hours in healthy volunteers receiving an intravenous injection [F85]. A half-life of approximately 6 hours has been reported in children [F85]., **Adult and paediatric patients with CRF:** The elimination half life following intravenous administration ranges from 4 to 13 hours, which is about 20% longer in CRF patients than that in healthy subjects. The half life is reported to be similar between adult patients receiving or not receiving dialysis [FDA Label]. , **Cancer patients receiving cyclic chemotherapy:** Following subcutaneous administration, the average half life is 40 hours with range of 16 to 67 hours [FDA Label].

FIRST PREV 1 2

Showing 3 records on this page Ã‚Â· Page 2 of 2