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MYP_119703
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Basic Information
Novel erythropoiesis stimulating protein (NESP)
Anticancer
Antiviral
Hormonal / Endocrine ▸ Hormone peptide
Standard
166 amino acids
C815H1317N233O241S5
Standard
Sequence
APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
Physicochemical Analysis
18395.92 Da
8.75
2.96
2.57
0.0178
-0.19
0.86
-0.02
36.76
96.45
0.0663
22460.00
22710.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
7649.41
-77.10
271.0
251.0
609.0
1294.0
24.0
178.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008388 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Five N-linked carbohydrate chains
Bio-Activity Profile
Stimulates erythropoiesis
ELISA
Subcutaneously injected into patients with end-stage renal failure, in vivo; 91080 s
PMID10541299 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10541299/
RECORD: Rec_0035352 VERIFIED: NO
Provenance & Taxonomy
Cricetulus griseus [Animal]
Enzyme
10029
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Glycosylation
Bio-Activity Profile
Anticancer
CHO
For subcutaneous dose: 7.37 hours
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1141
RECORD: Rec_0170745 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Chinese hamster ovary cell line [Animal]
Growth factor
9606; 10029
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
CHO
4 to 13 hours in CRF patients
RECORD: Rec_0222340 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
EPO/TPO family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-161; 29-33
Bio-Activity Profile
Hormone EPO TPO family
PaperPDB 1CN4 structural record; X-ray; 2.80 A; chain C; residues 1-166
RECORD: Rec_0296017 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Chinese hamster ovary cell line [Animal]
Growth factor
9606; 10029
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
CHO
4 hours in healthy volunteers receiving an intravenous injection
Evidence URLhttps://patents.google.com/patent/CA1339047/en PatentCA1339047
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