Peptide Database

Peptide NameSHP5

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC52H76N14O19

DescriptionStandard

        NEASYDISFR
    

Molecular Weight1201.24 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.1237

GRAVY Index-0.88

Hydrophobic Moment 0.18

Boman Index-0.19

Instability Index32.68

Aliphatic Index 49.00

Aromaticity 0.2000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 565.50

LogP -6.52

H-bond Donors 20.0

H-bond Acceptors 18.0

Rotatable Bonds 38.0

Heavy Atoms 85.0

Ring Count 2.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0123750 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFITC, 5(6)-carboxy fluorescence

C-TermNone

Other ModsStapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer Antimicrobial Antibacterial

PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13887. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/