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MYP_119649
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Basic Information
HIV-1 integrase(82-89)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
8 amino acids
C41H64N8O14
Standard
Sequence
GYIEAEVI
Physicochemical Analysis
892.99 Da
4.05
-2.24
-2.44
-0.2794
0.79
0.15
0.47
53.06
146.25
0.1250
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
361.85
-1.13
12.0
12.0
28.0
63.0
1.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009386 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
1000 μM
IC50
PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0055250 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
1000 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInterfacial peptide inhibitors of HIV-1 integrase activity and dimerization. | Zhao L, O'Reilly MK, Shultz MD, Chmielewski J. | Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7. | DOI:10.1016/s0960-894x(03)00040-4 | PMID:12643937 PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0318250 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
>1000 μM
IC50
PaperInterfacial peptide inhibitors of HIV-1 integrase activity and dimerization. PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0373936 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/