Peptide Database

Peptide NameDefensin-TK

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length59 amino acids

Chemical FormulaC281H425N69O79S7

DescriptionStandard

        LVFLVLVAITWGSSDGASPAIWGCDSFLGYCRLACFAHEASVGQKECAEGMLCCIPNVF
    

Molecular Weight6258.25 Da

Isoelectric Point (pI)4.50

Net Charge (pH 7.0)-3.20

Net Charge (pH 7.4) -3.55

Charge Density (pH 7.0) -0.0543

GRAVY Index0.82

Hydrophobic Moment 0.40

Boman Index0.36

Instability Index32.92

Aliphatic Index 95.93

Aromaticity 0.1186

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2296.01

LogP -18.76

H-bond Donors 85.0

H-bond Acceptors 84.0

Rotatable Bonds 195.0

Heavy Atoms 436.0

Ring Count 12.0

Amide Bonds 60.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086448 VERIFIED: YES

Provenance & Taxonomy

OrganismTheloderma kwangsiensis [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli ATCC 25922

Activity12 μg/mL

MethodMIC

RECORD: Rec_0105508 VERIFIED: YES

Provenance & Taxonomy

OrganismTheloderma kwangsiensis [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetB. dysenteriae

Activity3 μg/mL

MethodMIC

RECORD: Rec_0156695 VERIFIED: YES

Provenance & Taxonomy

OrganismTheloderma kwangsiensis [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC 2592

Activity3 μg/mL

MethodMIC

RECORD: Rec_0336853 VERIFIED: YES

Provenance & Taxonomy

OrganismTheloderma kwangsiensis [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity200 μg/mL

MethodHemolysis

RECORD: Rec_0391377 VERIFIED: YES

Provenance & Taxonomy

OrganismTheloderma kwangsiensis [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans ATCC 2002

Activity6 μg/mL

MethodMIC