Peptide Database

Peptide NameSLAY-screened peptide P763

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H147N27O28S

DescriptionStandard

        GCTPVTFHNVPYLITNNGFH
    

Molecular Weight2231.49 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0038

GRAVY Index0.03

Hydrophobic Moment 0.41

Boman Index0.27

Instability Index43.80

Aliphatic Index 68.00

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 866.19

LogP -8.65

H-bond Donors 29.0

H-bond Acceptors 31.0

Rotatable Bonds 63.0

Heavy Atoms 158.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0267220 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-Gram-negative Antibacterial Antimicrobial

TargetRecombinant genetically engineered Escherichia coli surface-display system

Activity-2.386 lfcMLE

MethodSLAY screening (log2 fold-change MLE)

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/