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MYP_119536
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Basic Information
Angiotensin I-converting enzyme inhibitor 4
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Calpain-1 inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Tripeptidyl Peptidase II Inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C14H20N2O4
Standard
Sequence
VY
Physicochemical Analysis
280.32 Da
5.49
-0.27
-0.48
-0.1335
1.45
0.53
0.67
-32.70
145.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
0.49
4.0
4.0
6.0
20.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0367373 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
7.1 μM
IC50
PaperNovel probiotic-fermented milk with angiotensin I-converting enzyme inhibitory peptides produced by Bifidobacterium bifidum MF 20/5. PMID24135669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24135669/
RECORD: Rec_0374142 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
0.33 Rcaf
Relative bitterness (Rcaf)
PaperBitterness of phenylalanine- and tyrosine-containing peptides. Agric. Biol. Chem., 51, 3309-3313, 1987
RECORD: Rec_0378537 VERIFIED: YES
Provenance & Taxonomy
Undaria pinnatifida [Plant]
74381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Angiotensin I-converting enzyme (ACE)
PaperAntihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats PMID15135150 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15135150/
RECORD: Rec_0379713 VERIFIED: NO
Provenance & Taxonomy
Oryza sativa [Plant]
ACE-inhibitory peptide
4530
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive Antioxidant
PaperVegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities. PMID23598136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23598136/
RECORD: Rec_0383516 VERIFIED: NO
Provenance & Taxonomy
Undaria pinnatifida [Protist]
ACE-inhibitory peptide
74381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperIs the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?
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