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MYP_119536
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Basic Information
Angiotensin I-converting enzyme inhibitor 4
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Calpain-1 inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Tripeptidyl Peptidase II Inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C14H20N2O4
Standard
Sequence
VY
Physicochemical Analysis
280.32 Da
5.49
-0.27
-0.48
-0.1335
1.45
0.53
0.67
-32.70
145.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
0.49
4.0
4.0
6.0
20.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019331 VERIFIED: YES
Provenance & Taxonomy
Oryza sativa [Plant]; Undaria pinnatifida [Plant]; Sardinops melanosticus [Plant]; Amaranthus hypochondriacus [Plant]; Triticum aestivum [Plant]
Angiotensin
4530
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Neuropeptide
7.1 μM
IC50
RECORD: Rec_0023699 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
5 mmHg
SBP decrease
PaperReview on the angiotensin-I-converting enzyme (ACE) inhibitor peptides from marine proteins. PMID23271625 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23271625/
RECORD: Rec_0026015 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
11 μM
IC50
Rat plasma, in vitro; 900 s
PMID14980787 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14980787/
RECORD: Rec_0036094 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
7.1
IC50
PaperSaito Y., Wanezaki K., Kawato A., Imayasu S.. Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58 (10), 1767-1771 (1994).
RECORD: Rec_0039431 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]; Viridiplantae [Plant]; Actinopterygii [Animal]; Sea bream [Plant]; Poaceae [Plant]; Pisum sativum [Plant]; Sus scrofa [Animal]; Insecta [Animal]; Fabaceae [Plant]
9913; 33090; 7898; 33090; 4479; 3888; 9823; 50557; 3803
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperWhat are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach PMID23871047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871047/
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