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MYP_119534
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Basic Information
MTEEY
Anticancer
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
5 amino acids
C28H41N5O12S
Standard
Sequence
MTEEY
Physicochemical Analysis
671.72 Da
4.05
-2.50
-2.72
-0.4990
-1.42
0.31
-0.13
105.96
0.00
0.2000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
294.78
-1.85
10.0
11.0
21.0
46.0
1.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0085586 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Antiproliferative Anticancer
HCT116 human colorectal cancer cells; CCD-33Co normal colon cells
Cell viability/cytotoxicity assay
PaperSelective mechanism of action of dietary peptides from common bean on HCT116 human colorectal cancer cells through loss of mitochondrial membrane potential and DNA damage
RECORD: Rec_0181410 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
3885.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Enzyme inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
90.3 μM
IC50
PaperLuna-Vital D. A., Gonzalez de Mejia E., Mendoza S., Loarca-Pina G.. Peptides present in the non-digestible fraction of common beans (Phaseolus vulgaris L.) inhibit the angiotensin-I converting enzyme by interacting with its catalytic cavity independent of their antioxidant capacity. Food Funct., 6, 1470-1479, 2015.
RECORD: Rec_0189789 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Enzyme inhibitory Antihypertensive
Angiotensin-I converting enzyme
90.3±0.35 μM
IC50
RECORD: Rec_0232787 VERIFIED: NO
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
3885.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperLuna-Vital D. A., Gonzalez de Mejia E., Mendoza S., Loarca-Pina G.. Peptides present in the non-digestible fraction of common beans (Phaseolus vulgaris L.) inhibit the angiotensin-I converting enzyme by interacting with its catalytic cavity independent of their antioxidant capacity. Food Funct., 6, 1470-1479, 2015.
RECORD: Rec_0258771 VERIFIED: NO
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Bioactive peptides
3885
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Immunomodulatory
PaperPubMed PMID 29287362 PMID29287362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29287362/
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