Peptide Database

Peptide NameUnnamed

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-1 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Lipase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Lipoxygenase Inhibitory

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC60H91N17O22

DescriptionStandard

        EQGFLPGPEESGR
    

Molecular Weight1402.47 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-2.16

Net Charge (pH 7.4) -2.33

Charge Density (pH 7.0) -0.1660

GRAVY Index-1.32

Hydrophobic Moment 0.42

Boman Index-0.14

Instability Index92.12

Aliphatic Index 30.00

Aromaticity 0.0769

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 632.06

LogP -7.47

H-bond Donors 20.0

H-bond Acceptors 20.0

Rotatable Bonds 44.0

Heavy Atoms 99.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0358737 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory COX-1 Inhibitory

TargetCyclooxygenase-1 (COX-1)

Activity4.79 μg/mL

MethodIC50

PaperZ?otek U., Jakubczyk A., Rybczy¨½ska-Tkaczyk K., ?wiek P., Baraniak B., Lewicki S.. Characteristics of new peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as inhibitors of enzymes involved in metabolic syndrome and antimicrobial potential. Molecules, 25, 2492, 2020. PMID32471271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32471271/

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