Peptide Database

Peptide NameSLAY-screened peptide P2354

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC94H131N19O22

DescriptionStandard

        WPVDSTLAFLSVFFLH
    

Molecular Weight1879.16 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.41

Charge Density (pH 7.0) -0.0720

GRAVY Index1.16

Hydrophobic Moment 0.25

Boman Index0.55

Instability Index24.06

Aliphatic Index 115.62

Aromaticity 0.2500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 633.49

LogP -1.10

H-bond Donors 22.0

H-bond Acceptors 22.0

Rotatable Bonds 53.0

Heavy Atoms 135.0

Ring Count 7.0

Amide Bonds 15.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0078156 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/