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MYP_119481
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Basic Information
Temporin-ALj
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C77H118N14O14
Standard
Sequence
FFPIVGKLLFGLL
Physicochemical Analysis
1463.85 Da
8.75
0.76
0.55
0.0584
2.00
0.35
0.76
-2.08
172.31
0.2308
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
429.75
2.73
14.0
15.0
45.0
105.0
4.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004790 VERIFIED: YES
Provenance & Taxonomy
Amolops loloensis [Animal]
Temporin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
7.5 μg/mL
MIC
PMID19843479 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19843479/
RECORD: Rec_0004953 VERIFIED: YES
Provenance & Taxonomy
Amolops loloensis [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperFive novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis. Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. doi: 10.1016/j.cbpb.2009.10.003. PMID: 19843479. PMID19843479 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19843479/
RECORD: Rec_0072257 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0090350 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 53.8%, E 0.0%, T 23.1%, C 23.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0104330 VERIFIED: YES
Provenance & Taxonomy
Amolops loloensis [Animal] [Animal]; Amolops jingdongensis [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
Candida albicans
5.00 μg/mL
MIC
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