Peptide Database

Peptide NameTP1[F4S] (Derived from TP1)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC93H150N34O21S4

DescriptionStandard

        KWCSRVCYRGICYRRCR
    

Molecular Weight2208.66 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3363

GRAVY Index-0.73

Hydrophobic Moment 0.62

Boman Index-0.52

Instability Index24.55

Aliphatic Index 40.00

Aromaticity 0.1765

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.92

LogP -8.73

H-bond Donors 42.0

H-bond Acceptors 31.0

Rotatable Bonds 71.0

Heavy Atoms 152.0

Ring Count 4.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322067 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetKlebsiella pneumoniae ATCC 13883

Activity2 μg/mL

MethodMIC

RECORD: Rec_0325518 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetPseudomonas aeruginosa ATCC 27853

Activity4 μg/mL

MethodMIC

RECORD: Rec_0399089 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus ATCC 43300 (MRSA)

Activity16 μg/mL

MethodMIC

RECORD: Rec_0410198 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetAcinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)

Activity2 μg/mL

MethodMIC

RECORD: Rec_0411978 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

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