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MYP_119348
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Basic Information
Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
97 amino acids
C451H744N136O136S8
Standard
Sequence
MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
Physicochemical Analysis
10504.08 Da
8.30
1.46
1.14
0.0150
0.18
0.59
0.04
46.10
97.53
0.0515
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4391.68
-48.69
162.0
146.0
350.0
731.0
9.0
103.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0189579 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Evidence URLhttps://patents.google.com/patent/US20090264344A1/en PatentUS 2009/0264344 A1
RECORD: Rec_0199146 VERIFIED: NO
Provenance & Taxonomy
Pan paniscus [Animal]
Defensin
9597
Structure & Mods
linear polypeptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Antifungal Fungicide Non-hemolytic
Qualitative functional evidence
Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22722832/
RECORD: Rec_0265353 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606.0
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-HSV
HIV-1, HSV-1, HSV-2
PaperRetrocyclins: Antiviral and Antimicrobial Peptides Evidence URLhttps://patents.google.com/patent/US20090264344A1/en PatentUS 2009/0264344 A1
RECORD: Rec_0278613 VERIFIED: NO
Provenance & Taxonomy
Pan paniscus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ7206
RECORD: Rec_0341774 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID8469233;16421571;15489334;2843187;2500436;2501794;15317502;15616305;15620707;17088326;30658057;16959974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8469233/
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