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MYP_119348
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Basic Information
Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
97 amino acids
C451H744N136O136S8
Standard
Sequence
MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
Physicochemical Analysis
10504.08 Da
8.30
1.46
1.14
0.0150
0.18
0.59
0.04
46.10
97.53
0.0515
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4391.68
-48.69
162.0
146.0
350.0
731.0
9.0
103.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051648 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
S. faecalis (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID8469233;16421571;15489334;2843187;2500436;2501794;15317502;15616305;15620707;17088326;30658057;16959974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8469233/
RECORD: Rec_0069573 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID8469233;16421571;15489334;2843187;2500436;2501794;15317502;15616305;15620707;17088326;30658057;16959974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8469233/
RECORD: Rec_0087897 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Candida albicans
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID8469233;16421571;15489334;2843187;2500436;2501794;15317502;15616305;15620707;17088326;30658057;16959974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8469233/
RECORD: Rec_0154536 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
B. anthracis (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID8469233;16421571;15489334;2843187;2500436;2501794;15317502;15616305;15620707;17088326;30658057;16959974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8469233/
RECORD: Rec_0177119 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
B. cereus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID8469233;16421571;15489334;2843187;2500436;2501794;15317502;15616305;15620707;17088326;30658057;16959974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8469233/
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