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MYP_119293
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Basic Information
a-p9
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C48H90N16O12S3
Standard
Sequence
LMRIRQMMT
Physicochemical Analysis
1179.52 Da
12.00
1.76
1.56
0.1956
0.09
0.45
-0.18
15.51
86.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
483.24
-3.20
18.0
17.0
42.0
79.0
0.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0089442 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Porcine reproductive and respiratory syndrome virus (Replication); MARC-145
263.8101 μM
MTT assay
PaperAntiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro. | Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P. | Virology. 2012 | PMID:22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0109493 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
MARC-145 cells (50% Cell death at >500 microM
145 μM
Hemolysis
PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0185899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-RSV Replication inhibition
Porcine reproductive and respiratory syndrome virus (PRRSV) | MARC-145 cells
263.8 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro. | Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P. | Virology. 2012 Oct 10;432(1):73-80. | DOI:10.1016/j.virol.2012.05.010 | PMID:22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0287240 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0335788 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
MARC-145 cells
500 μM
CC50
PaperPubMed PMID: 22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
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