Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length502 amino acids

Chemical FormulaC2458H3899N633O727S22

DescriptionStandard

        MLSCSFPDNQRSRDRDQRHYCNITRVDMVSLWSALALLTFFSPEASGTNPGVIVRVTQKGLEYGRQIGLVTLQKKLKTVKIPDMSGSEKVSPIGEVSYSLTGIQILDLGLPKSAVGLVPGTGVSLFIGDAYINLHGNWRVKYLRIIKDSGSFDLSVSGLSISATISVKGDDTGRPVVSSANCAASVGNVNIKFHGGASWLYNLFKDYIDKALRNALQKQICSLVAEAIDEMNPHLKTLNVLAQVDKYAEIEYSMVESPLMSNSSIDLSLKGEFYNIGQHKEPPFSPTPFSLPAQDSNMMYIGLSAFTLNSAGFVYNNAGVLSLYITDDMIPSSFPIRLNTKTFGTFIPQIAKQYPGLMMKLLVKAEKEPNVSFEPNNVTLQASSTVTAYAIQPNATLSPLFVLNMNASVSARIYLSGLSVAGNLSLNEMDMALAMSYVGPFQVKSLDSFLNMIMKAVVIPVVNAFLQQGYPLPAIGNMNLVNTQLQILKDYLLIGTDVQFTG
    

Molecular Weight54655.48 Da

Isoelectric Point (pI)7.60

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0018

GRAVY Index0.12

Hydrophobic Moment 0.75

Boman Index0.15

Instability Index36.42

Aliphatic Index 99.80

Aromaticity 0.0857

Extinction Coeff. Reduced 44810.00

Extinction Coeff. Oxidized 45060.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0201327 VERIFIED: NO

Provenance & Taxonomy

OrganismAmeiurus melas (Black bullhead) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria