Peptide Database

Peptide NameSLAY-screened peptide P4167

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H158N34O37

DescriptionStandard

        SDFNEYKSDSRRDLRSSTHK
    

Molecular Weight2428.53 Da

Isoelectric Point (pI)8.24

Net Charge (pH 7.0)0.55

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0275

GRAVY Index-2.07

Hydrophobic Moment 0.51

Boman Index-0.68

Instability Index106.70

Aliphatic Index 19.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1216.54

LogP -17.63

H-bond Donors 45.0

H-bond Acceptors 39.0

Rotatable Bonds 84.0

Heavy Atoms 171.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0187165 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/