Peptide Database

Peptide NameNosiheptide (NOS; Antibiotic 9671-RP)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC40H68N12O20S6

DescriptionStandard

        SCTTCECCCSCS
    

Molecular Weight1229.43 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.89

Charge Density (pH 7.0) -0.1330

GRAVY Index0.64

Hydrophobic Moment 0.10

Boman Index0.03

Instability Index127.28

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 521.87

LogP -11.09

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 37.0

Heavy Atoms 78.0

Ring Count 0.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403682 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces actuosus [Bacterium]

Structure & Mods

Configbimacrocyclic thiopeptide scaffold [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsExtensively post-translationally modified thiopeptide (thiazoles, dehydroamino acids, hydroxypyridine macrocycle and indole side ring)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Ribosomal translation inhibitor Thiopeptide antibiotic

TargetViridans group streptococci

Activity0.0065 μg/mL

MethodMIC

RECORD: Rec_0404363 VERIFIED: YES