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MYP_119076
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Basic Information
Nosiheptide (NOS; Antibiotic 9671-RP)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
12 amino acids
C40H68N12O20S6
Standard
Sequence
SCTTCECCCSCS
Physicochemical Analysis
1229.43 Da
4.05
-1.60
-1.89
-0.1330
0.64
0.10
0.03
127.28
0.00
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
521.87
-11.09
25.0
25.0
37.0
78.0
0.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0314960 VERIFIED: YES
Provenance & Taxonomy
Streptomyces actuosus [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Lactobacillus casei strain ATCC 6633
0.003 μg/mL
MIC
PMID19678698;18406324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19678698/
RECORD: Rec_0322832 VERIFIED: YES
Provenance & Taxonomy
Streptomyces actuosus [Bacterium]
thiocillin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-Glu: 4-hydroxyglutamate; 12-Ser: 2,3-didehydroalanine (Ser)
Bio-Activity Profile
Antimicrobial thiocillin family Host defense
PaperPDB 2ZJP structural record; X-ray; 3.70 A; chain 5; residues 1-12
RECORD: Rec_0363816 VERIFIED: YES
Provenance & Taxonomy
Streptomyces actuosus [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pyogenes hemolyticus strain Dig7
0.00028 μg/mL
MIC
PMID19678698;18406324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19678698/
RECORD: Rec_0373128 VERIFIED: YES
Provenance & Taxonomy
Streptomyces actuosus [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
lysodeikticus strain ATCC 4698
0.003 μg/mL
MIC
PMID19678698;18406324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19678698/
RECORD: Rec_0380022 VERIFIED: YES
Provenance & Taxonomy
Streptomyces actuosus [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID19678698;18406324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19678698/
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