Peptide Database

Peptide NameNosiheptide (NOS; Antibiotic 9671-RP)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC40H68N12O20S6

DescriptionStandard

        SCTTCECCCSCS
    

Molecular Weight1229.43 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.89

Charge Density (pH 7.0) -0.1330

GRAVY Index0.64

Hydrophobic Moment 0.10

Boman Index0.03

Instability Index127.28

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 521.87

LogP -11.09

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 37.0

Heavy Atoms 78.0

Ring Count 0.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0056279 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces actuosus [Bacterium]

Structure & Mods

Configbimacrocyclic thiopeptide scaffold [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsExtensively post-translationally modified thiopeptide (thiazoles, dehydroamino acids, hydroxypyridine macrocycle and indole side ring)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Ribosomal translation inhibitor Thiopeptide antibiotic

TargetPasteurella multocida strain A125

Activity0.0024 μg/mL

MethodMIC

RECORD: Rec_0093005 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces actuosus [Bacterium]

Structure & Mods

Configbimacrocyclic thiopeptide scaffold [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsExtensively post-translationally modified thiopeptide (thiazoles, dehydroamino acids, hydroxypyridine macrocycle and indole side ring)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Ribosomal translation inhibitor Thiopeptide antibiotic

TargetStaphylococcus aureus strain B3

Activity0.003 μg/mL

MethodMIC

RECORD: Rec_0118752 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces actuosus [Bacterium]

Structure & Mods

Configbimacrocyclic thiopeptide scaffold [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsExtensively post-translationally modified thiopeptide (thiazoles, dehydroamino acids, hydroxypyridine macrocycle and indole side ring)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Ribosomal translation inhibitor Thiopeptide antibiotic

TargetBacillus cereus ATCC 6630 and various isolates of Listeria monocytogenes

Activity0.0071 μg/mL

MethodMIC

RECORD: Rec_0139381 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces actuosus [Bacterium]

Structure & Mods

Configbimacrocyclic thiopeptide scaffold [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsExtensively post-translationally modified thiopeptide (thiazoles, dehydroamino acids, hydroxypyridine macrocycle and indole side ring)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Ribosomal translation inhibitor Thiopeptide antibiotic

TargetEnterococcus faecalis strain ATCC 9790

Activity0.0007 μg/mL

MethodMIC

RECORD: Rec_0141374 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces actuosus [Bacterium]

Structure & Mods

Configbimacrocyclic thiopeptide scaffold [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsExtensively post-translationally modified thiopeptide (thiazoles, dehydroamino acids, hydroxypyridine macrocycle and indole side ring)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Ribosomal translation inhibitor Thiopeptide antibiotic

TargetStaphylococcus aureus strain Hb

Activity0.003 μg/mL

MethodMIC

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