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MYP_118765
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Basic Information
peptide 27 (Derived from B1)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KKKXAYA
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0231945 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
64 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0238291 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
MSSA ATCC 29213
64 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0271174 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0399994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: MRSP C22963
2-4 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0418005 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/