Peptide Database

Peptide NameSLAY-screened peptide P2236

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC92H149N27O28S

DescriptionStandard

        YRPTNANVTTHATLALAVPC
    

Molecular Weight2113.40 Da

Isoelectric Point (pI)8.23

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.57

Charge Density (pH 7.0) 0.0418

GRAVY Index0.18

Hydrophobic Moment 0.19

Boman Index0.14

Instability Index4.78

Aliphatic Index 88.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 876.55

LogP -10.51

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 60.0

Heavy Atoms 148.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0156343 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/