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MYP_118467
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Virucidal activity
Standard
20 amino acids
C98H178N28O21
Standard
Sequence
RRKKAAVALLPAVLLALLAP
Physicochemical Analysis
2084.64 Da
12.00
3.76
3.55
0.1879
1.10
0.32
0.22
67.03
176.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
774.48
-2.89
27.0
25.0
67.0
147.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0235133 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza virus Replication inhibition
Influenza virus | MDCK cells
3.2±0 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperIdentification of the minimal active sequence of an anti-influenza virus peptide. | Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. | Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3. | DOI:10.1128/AAC.01428-10 | PMID:21220525 PMID21220525 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21220525/
RECORD: Rec_0264508 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Signal peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Monkeypox virus (Virus entry); BSC-1
48.6 μM
EC50
PaperAntiviral activity of the EB peptide against zoonotic poxviruses. | Altmann SE, Brandt CR, Jahrling PB, Blaney JE. | Virol J. 2012 | PMID:22225618 PMID22225618 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22225618/
RECORD: Rec_0266475 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Signal peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Influenza A virus (Virus entry); cRBCs
8 μM
Hemagglutinin assay
PaperInhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. | Jones JC, Turpin EA, Bultmann H, Brandt CR, Schultz-Cherry S. | J Virol. 2006 | PMID:17005658 PMID17005658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17005658/
RECORD: Rec_0273531 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Signal peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Cowpox virus (Virus entry); BSC-1
26.3 μM
EC50
PaperAntiviral activity of the EB peptide against zoonotic poxviruses. | Altmann SE, Brandt CR, Jahrling PB, Blaney JE. | Virol J. 2012 | PMID:22225618 PMID22225618 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22225618/
RECORD: Rec_0353530 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
EB peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-HSV Anti-Influenza Entry inhibitor
HSV-1
15-26 μM
IC50
PaperThe virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner; Patent: Method of inhibiting influenza infection with antiviral peptides PMID20643896 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20643896/ PatentUS 7432045 B2
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