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MYP_118467
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Virucidal activity
Standard
20 amino acids
C98H178N28O21
Standard
Sequence
RRKKAAVALLPAVLLALLAP
Physicochemical Analysis
2084.64 Da
12.00
3.76
3.55
0.1879
1.10
0.32
0.22
67.03
176.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
774.48
-2.89
27.0
25.0
67.0
147.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0106697 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
EB peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-Influenza
Influenza virus
2.6 ± 1.0 μM
EC50
PaperThe virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner; Patent: Novel Antiviral Peptides Against Influenza Virus PMID20643896 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20643896/ PatentUS 20100041604
RECORD: Rec_0108251 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Signal peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Vaccinia virus (Virus entry); HeLa
0.26 mOD/min
Plaque assay
PaperInhibition of Vaccinia virus entry by a broad spectrum antiviral peptide. | Altmann SE, Jones JC, Schultz-Cherry S, Brandt CR. | Virology. 2009 | PMID:19395056 PMID19395056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19395056/
RECORD: Rec_0157223 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Signal peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Herpes simplex virus 1 (Virus entry); Vero
0.7 μM
Plaque assay
PaperModified FGF4 signal peptide inhibits entry of herpes simplex virus type 1. | Bultmann H, Busse JS, Brandt CR. | J Virol. 2001 | PMID:11222686 PMID11222686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11222686/
RECORD: Rec_0181056 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza virus Replication inhibition
Inhibition of influenza virus-induced cell death and replication in vitro
4.5 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperInhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. | Jones JC, Turpin EA, Bultmann H, Brandt CR, Schultz-Cherry S. | J Virol. 2006 Dec;80(24):11960-7. | DOI:10.1128/JVI.01678-06 | PMID:17005658 PMID17005658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17005658/
RECORD: Rec_0227387 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus(A/Hong Kong/483/97 ([HK/483] strain H5N1))
8 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperInhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. | Jones JC, Turpin EA, Bultmann H, Brandt CR, Schultz-Cherry S. | J Virol. 2006 Dec;80(24):11960-7. | DOI:10.1128/JVI.01678-06 | PMID:17005658 PMID17005658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17005658/
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