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MYP_118467
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Virucidal activity
Standard
20 amino acids
C98H178N28O21
Standard
Sequence
RRKKAAVALLPAVLLALLAP
Physicochemical Analysis
2084.64 Da
12.00
3.76
3.55
0.1879
1.10
0.32
0.22
67.03
176.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
774.48
-2.89
27.0
25.0
67.0
147.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000039 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0003813 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
EB peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-HSV Anti-Influenza Entry inhibitor Virucidal
HSV-1
21 μM
IC50
PaperThe virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner; Patent: Method of inhibiting influenza infection with antiviral peptides PMID20643896 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20643896/ PatentUS 7432045 B2
RECORD: Rec_0029335 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Signal peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Vaccinia virus (Virus entry); HeLa
-0.27 mOD/min
Plaque assay
PaperInhibition of Vaccinia virus entry by a broad spectrum antiviral peptide. | Altmann SE, Jones JC, Schultz-Cherry S, Brandt CR. | Virology. 2009 | PMID:19395056 PMID19395056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19395056/
RECORD: Rec_0083167 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
EB peptide
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Anti-HSV Entry inhibitor
And adenoviruses.The peptide shows antiviral activity against HSV by blocking virus entry
15-26 μM
IC50
PaperThe virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner; Patent: Pharmacologically active antiviral peptides and methods of their use PMID20643896 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20643896/ PatentUS 20050130884
RECORD: Rec_0102303 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Evidence URLhttps://patents.google.com/patent/US20050130884A1/en PatentUS 2005/0130884 A1
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