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MYP_118432
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Basic Information
Semastatin-5B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
19 amino acids
C83H125N29O28S2
Standard
Sequence
TSWSPCSASCGGGHYQRTR
Physicochemical Analysis
2041.19 Da
8.94
1.46
1.19
0.0771
-0.97
0.32
-0.17
81.91
5.26
0.1053
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
931.30
-15.43
37.0
33.0
61.0
142.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096712 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombospondin type-1 repeat
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
HUVEC
WST-1 proliferation assay
PaperAnti-angiogenic peptides identified in thrombospondin type I domains PMID17531201 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17531201/
RECORD: Rec_0098483 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombospondin type-1 repeat
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
HUVEC
Boyden chamber migration assay
PaperAnti-angiogenic peptides identified in thrombospondin type I domains PMID17531201 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17531201/
RECORD: Rec_0145826 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0153168 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Semastatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
Endothelial screening context
PaperSupporting Information for Karagiannis and Popel, PNAS (10.1073/pnas.0803241105) PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0174061 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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