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MYP_118404
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Basic Information
Bovine tracheal antimicrobial peptide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
38 amino acids
C169H302N58O45S7
Standard
Sequence
NPVSCVRNKGICVPIRCPGSMKQIGTCVGRAVKCCRKK
Physicochemical Analysis
4091.02 Da
10.00
8.70
8.40
0.2288
-0.09
0.69
-0.15
32.82
71.58
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1681.31
-20.77
65.0
61.0
138.0
279.0
3.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0287763 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa 27853
25-50 μg/mL
MIC
PMID2023943;8506305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2023943/
RECORD: Rec_0324294 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bridges: 5,34; 12,27; 17,35;
Bio-Activity Profile
Antimicrobial Antifungal
Klebsiella pneumoniae ATCC 13883
12-25 μg/mL
MIC
PaperTracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.
RECORD: Rec_0339141 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bridges: 5,34; 12,27; 17,35;
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC 14053
6-12 μg/mL
MIC
PaperTracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.
RECORD: Rec_0363212 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 25923
25-50 μg/mL
MIC
PMID2023943 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2023943/
RECORD: Rec_0426447 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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