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MYP_118367
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Basic Information
Mastoparan M
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
14 amino acids
C70H130N18O16
Standard
Sequence
INLKAIAALAKKLL
Physicochemical Analysis
1479.89 Da
10.30
2.76
2.55
0.1969
1.16
0.58
0.30
-2.84
195.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
562.77
-1.68
19.0
19.0
53.0
104.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0134078 VERIFIED: YES
Provenance & Taxonomy
Vespa mandarinia [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Mast cell degranulating Histamine release Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rat peritoneal mast cells
0.5 nmol/mL
Minimum mast-cell-degranulating concentration; mast cell degranulation assay
PaperBiomed. Res. 1981; 2: 447-449 | http://www.uniprot.org/uniprot/P04205 Evidence URLhttps://www.uniprot.org/uniprotkb/P04205/entry
RECORD: Rec_0159386 VERIFIED: YES
Provenance & Taxonomy
Vespa mandarinia [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus xylosus
2 μg/mL
MIC
PaperA new mast cell degranulating peptide, mastoparan-M, in the venom of the hornet Vespa mandarinia.
RECORD: Rec_0182171 VERIFIED: YES
Provenance & Taxonomy
Vespa magnifica [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus isolates
6.0±3.5; 6.0±3.5 mg/L
MIC; MBC
PaperPubMed PMID: 15935330 | PubMed PMID: 27591703 PMID15935330;27591703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15935330/
RECORD: Rec_0199368 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-Gram-negative Antibacterial Antimicrobial
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0206585 VERIFIED: YES
Provenance & Taxonomy
Vespa mandarinia [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antifungal
Neurospora crassa, Botrytis cinerea, Fusarium culmorum
1-3 μM
IC50
PaperA new mast cell degranulating peptide, mastoparan-M, in the venom of the hornet Vespa mandarinia.
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