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MYP_118317
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
39 amino acids
C182H268N62O48S8
Standard
Sequence
GFGCPNNYQCHRHCKSIPGRCGGYCGGWHRLPCTCYRCG
Physicochemical Analysis
4348.98 Da
8.94
4.94
4.46
0.1266
-0.65
0.60
-0.10
45.72
20.00
0.1282
9970.00
10470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1748.62
-21.80
70.0
64.0
131.0
300.0
12.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0239911 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0275560 VERIFIED: YES
Provenance & Taxonomy
Mytilus galloprovincialis [Animal]
Defensin
29158
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperBiochemistry 2000 Nov 28;39(47):14436-47 | http://www.ncbi.nlm.nih.gov/pubmed/11087396 PMID11087396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087396/
RECORD: Rec_0320490 VERIFIED: YES
Provenance & Taxonomy
Mytilus galloprovincialis [Animal]
Defensin
29158
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains 4 disulfide bonds (C4-C25, C10-C33, C14-C35, and C21-C38) among which the fourth S-S bond is not important for antibacterial activity. Trp28 is hydroxylated. This hydroxylation appears no to influence antimicrobial activity
Bio-Activity Profile
Antimicrobial
vibrio P1
6.4 μg/mL
MIC
PaperA member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis)
RECORD: Rec_0347070 VERIFIED: YES
Provenance & Taxonomy
Mytilus galloprovincialis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0349526 VERIFIED: YES
Provenance & Taxonomy
Mytilus galloprovincialis [Animal]
Defensin
29158
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains 4 disulfide bonds (C4-C25, C10-C33, C14-C35, and C21-C38) among which the fourth S-S bond is not important for antibacterial activity. Trp28 is hydroxylated. This hydroxylation appears no to influence antimicrobial activity
Bio-Activity Profile
Antimicrobial
V. alginolyticus
6.4 μg/mL
MIC
PaperA member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis)
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