Peptide Database

Peptide NameAntihemophilic Factor

Function Ontology

Hemostasis ▸ Anticoagulant activity

Hemostasis ▸ Antithrombotic activity

Standard StatusStandard

Sequence Length255 amino acids

Chemical FormulaC1307H1999N345O374S9

DescriptionStandard

        ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYW
    

Molecular Weight28817.53 Da

Isoelectric Point (pI)7.29

Net Charge (pH 7.0)0.57

Net Charge (pH 7.4) -0.19

Charge Density (pH 7.0) 0.0023

GRAVY Index-0.31

Hydrophobic Moment 0.76

Boman Index0.03

Instability Index32.82

Aliphatic Index 80.63

Aromaticity 0.1137

Extinction Coeff. Reduced 56380.00

Extinction Coeff. Oxidized 56505.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0276674 VERIFIED: YES

Provenance & Taxonomy

OrganismCricetulus griseus [Animal]

FamilyCoagulation factor

Tax ID10029

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticoagulant Antithrombotic Hemostatic Coagulation factor replacement

Half-Life8.4-19.3 h

PaperPubMed-linked source references: PMID:23803235; PMID:23105376; PMID:8328652; PMID:2341766; PMID:4708094; PMID:2831669; PMID:27445511; PMID:25136251; PMID:6197726 PMID23803235;23105376;8328652;2341766;4708094;2831669;27445511;25136251;6197726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23803235/ PatentCA2124690