Peptide Database

Peptide NameAVIToxin-VAR1

Function Ontology

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length85 amino acids

Chemical FormulaC399H632N114O116S11

DescriptionStandard

        AVITGACDKDLQCGEGMCCAVSLWIRSIRICTPLGSSGEDCHPLSHKVPFDGQRKHHTCPCLPNLVCGQTSPGKYKCLPEFKNVF
    

Molecular Weight9234.70 Da

Isoelectric Point (pI)8.12

Net Charge (pH 7.0)2.05

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0241

GRAVY Index-0.11

Hydrophobic Moment 0.61

Boman Index0.04

Instability Index57.09

Aliphatic Index 71.06

Aromaticity 0.0588

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3617.60

LogP -39.04

H-bond Donors 132.0

H-bond Acceptors 133.0

Rotatable Bonds 296.0

Heavy Atoms 640.0

Ring Count 17.0

Amide Bonds 89.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0423643 VERIFIED: YES

Provenance & Taxonomy

OrganismVaranus varius [Animal]

FamilyAVIToxin-VAR1

Tax ID8559

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Receptor modulation

Targetcontracts gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour