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MYP_118161
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Basic Information
Lariatins A (lasso peptide; Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
18 amino acids
C94H145N27O26
Standard
Sequence
GSQLVYREWVGHSNVIKP
Physicochemical Analysis
2069.32 Da
8.60
0.85
0.59
0.0471
-0.41
0.38
0.04
-20.13
91.67
0.1111
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
865.79
-7.51
30.0
28.0
65.0
147.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075790 VERIFIED: YES
Provenance & Taxonomy
Rhodococcus jostii [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Mycobacterium smegmatis and Mycobacterium tuberculosis
PaperPubMed PMID: 16756302 PMID16756302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16756302/
RECORD: Rec_0124432 VERIFIED: YES
Provenance & Taxonomy
Rhodococcus jostii [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0210941 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0261070 VERIFIED: YES
Provenance & Taxonomy
Rhodococcus jostii [Bacterium]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
there is an intramolecular amide bond between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1
Bio-Activity Profile
Antimicrobial
Gram-positive Mycobacterium smegmatis
PaperLariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure
RECORD: Rec_0416334 VERIFIED: YES
Provenance & Taxonomy
Rhodococcus jostii K01-B0171 [other]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16756302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16756302/