Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length439 amino acids

Chemical FormulaC2224H3498N602O619S8

DescriptionStandard

        HQHGIAMLEKELARLTLPDISGDFRVLRVGKVHYELSRLRLRNFHLPYSRISPVPSVGLQVSISNAFAELDGDWRVKMLFIRDHGSFDLKVENVYIKISLRLGNDAAGKPTISTSDCSTRISKVRVLFSGKFAWLYNLFHSAIESKFKKILESKVCDSVEESVHSELQTYIRTLPVTAKIDARTGIDYSFVAPPVATAQSLDTGLKGEFYSLAHHSTAPFSPLPLSLPSDHDRMVYFGASNYFFNTAGFAYHTSGALVFEITDATIPKDVDFHLNTSTFSAFVPQLEQMYPNTPMKLRLSTLTAPFLNIGPGGISLKPIVDVQAYAILPSSSLAPLFVLSLVRNVSAVIDVRSGHIVGSLNVGRYRGERPLLGRGRLGVRQLQSIMNIVASQILLPRLNARLDEGFPLPLPDRIQLLNTFVRFHQNFLLLGADVHFQPK
    

Molecular Weight48829.75 Da

Isoelectric Point (pI)9.42

Net Charge (pH 7.0)10.08

Net Charge (pH 7.4) 9.01

Charge Density (pH 7.0) 0.0230

GRAVY Index0.05

Hydrophobic Moment 0.69

Boman Index0.09

Instability Index35.69

Aliphatic Index 101.91

Aromaticity 0.0957

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108729 VERIFIED: NO

Provenance & Taxonomy

OrganismPachyramphus minor [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria